Prognostic significance of LRPPRC and its association with immune infiltration in liver hepatocellular carcinoma

• Published in: American journal of clinical and experimental immunology Vol. 13; no. 3; pp. 105 - 116
• Main Authors: Zhang, Yanqiu, Feng, Bin, Liang, Yuting, Tang, Qingqin, Zhang, Sheng, Zhang, Zheng, Xu, Li, Yin, Jingping
• Format: Journal Article
• Language: English
• Published: United States e-Century Publishing Corporation 01-01-2024
• Subjects: Original; liver hepatocellular carcinoma (LIHC); immune infiltration; prognostic value; LRPPRC
• ISSN: 2164-7712; 2164-7712
• DOI: 10.62347/XTLJ1335

Leucine rich pentatricopeptide repeat containing (LRPPRC) protein is a multifunctional protein involved in cell cycle progression and tumor development. However, its prognostic significance and association with immune infiltration in Liver hepatocellular carcinoma (LIHC) remain unclear.
We utilized transcriptomic and clinical data from The Cancer Genome Atlas (TCGA) and Genotype Tissue Expression (GTEx) databases of LIHC patients to investigate the potential pro-cancer role of LRPPRC, including differential expression of LRPPRC in LIHC, prognostic value, clinicopathological features, immune cell infiltration relevance and function enrichment analysis.
Our findings suggest that LRPPRC is upregulated in LIHC and exhibits correlations with survival, clinical stage, and tumor grade in LIHC patients. Additionally, immune infiltration analysis revealed significant negative correlations between LRPPRC expression and multiple tumor-infiltrating immune cells, including CTLs, DCs, pDCs, B cells, Th17 cells, neutrophils, T cells, Mast cells, Th1 cells, Tregs, and NK cells, whereas a significant positive correlation was observed with infiltration of Th2 cells, T helper cells and Tcms. Furthermore, functional enrichment analysis indicated that LRPPRC may be involved in G2m checkpoint, mitotic spindle, E2f targets, Wnt Beta catenin signaling, spermatogenesis and other processes.