Primary metastatic leiomyosarcoma of the fallopian tube: a rare case report

• Published in: Onkologie Vol. 33; no. 1-2; p. 49
• Main Authors: Jacobs, Volker R, Zemzoum, Iris, Kremer, Marcus, Gottschalk, Nina, Baumgärtner, Anne K, Krol, Janna, Kiechle, Marion
• Format: Journal Article
• Language: English
• Published: Switzerland 01-01-2010
• Subjects: Combined Modality Therapy; Diagnostic Imaging; Disease Progression; Fallopian Tube Neoplasms - diagnosis; Fallopian Tube Neoplasms - pathology; Fallopian Tube Neoplasms - therapy; Fallopian Tubes - pathology; Fatal Outcome; Female; Humans; Leiomyosarcoma - diagnosis; Leiomyosarcoma - pathology; Leiomyosarcoma - secondary; Leiomyosarcoma - therapy; Liver - pathology; Liver Neoplasms - diagnosis; Liver Neoplasms - pathology; Liver Neoplasms - secondary; Liver Neoplasms - therapy; Middle Aged; Neoplasm Invasiveness - pathology; Neoplasm Staging; Palliative Care; Peritoneal Neoplasms - diagnosis; Peritoneal Neoplasms - pathology; Peritoneal Neoplasms - secondary; Peritoneal Neoplasms - therapy; Prognosis
• ISSN: 1423-0240
• DOI: 10.1159/000264625

Leiomyosarcoma of the fallopian tube is an extremely unusual gynecologic neoplasm. Since 1886, only 19 of about 35 sarcomas of the fallopian tube have been identified as leiomyosarcomas. As such, clinical diagnosis and therapy management are difficult.
We report on the case of a 59-year-old woman with leiomyosarcoma of the fallopian tube and liver metastases at the time of diagnosis. After initial tumor debulking, she received palliative chemotherapy with gemcitabine 900 mg/m(2) (d1+8) and docetaxel 100 mg/m(2) (d8) (q21). For additional bone metastases, she started local radiation plus bisphosphonates (q28). After 2 cycles of chemotherapy, the disease progressed, and the patient died within 8 months of diagnosis. A review of the literature is given.
Primary metastatic leiomyosarcoma of the fallopian tube is a progressive disease with limited therapy options. For better prognostic evaluation and disease management in such rare cases, it is important to report and compare more cases regarding course of disease and outcome.