Minimizing Antibiotic Use in Urethral Reconstruction

• Published in: The Journal of urology Vol. 208; no. 1; pp. 128 - 134
• Main Authors: Kim, Sunchin, Cheng, Katherine C, Alsikafi, Nejd F, Breyer, Benjamin N, Broghammer, Joshua A, Elliott, Sean P, Erickson, Bradley A, Myers, Jeremy B, Smith, 3rd, Thomas G, Vanni, Alex J, Voelzke, Bryan B, Zhao, Lee C, Buckley, Jill C
• Format: Journal Article
• Language: English
• Published: United States 01-07-2022
• Subjects: Anti-Bacterial Agents - therapeutic use; Humans; Male; Middle Aged; Postoperative Complications - etiology; Retrospective Studies; Urethra - surgery; Urethral Stricture - etiology; Urinary Tract Infections - epidemiology; Urinary Tract Infections - etiology; Urinary Tract Infections - prevention & control; Urologic Surgical Procedures; Urologic Surgical Procedures, Male - methods; Wound Infection - drug therapy; Wound Infection - etiology; Wound Infection - surgery; anti-bacterial agents; urethral stricture; urethroplasty
• ISSN: 0022-5347; 1527-3792
• DOI: 10.1097/JU.0000000000002487

There are no established guidelines regarding management of antibiotics for patients specifically undergoing urethral reconstruction. Our aim was to minimize antibiotic use by following a standardized protocol in the pre-, peri- and postoperative setting, and adhere to American Urological Association antibiotic guidelines. We hypothesized that prolonged suppressive antibiotics post-urethroplasty does not prevent urinary tract infection and/or wound infection rates.
We prospectively treated 900 patients undergoing urethroplasty or perineal urethrostomy at 11 centers over 2 years. The first-year cohort A received prolonged postoperative antibiotics. Year 2, cohort B, did not receive prolonged antibiotics. A standardized protocol following the American Urological Association guidelines for perioperative antibiotics was used. The 30-day postoperative infectious complications were determined. We used chi-square analysis to compare the cohorts, and multivariate logistic regression to identify risk factors.
The mean age of participants in both cohorts was 49.7 years old and the average stricture length was 4.09 cm. Overall, the rate of postoperative urinary tract infection and wound infection within 30 days was 5.1% (6.7% in phase 1 vs 3.9% in phase 2, p=0.064) and 3.9% (4.1% in phase 1 vs 3.7% in phase 2, p=0.772), respectively. Multivariate logistic regression analysis of patient characteristics and operative factors did not reveal any factors predictive of postoperative infections.
The use of a standardized protocol minimized antibiotic use and demonstrated no benefit to prolonged antibiotic use. There were no identifiable risk factors when considering surgical characteristics. Given the concern of antibiotic over-prescription, we do not recommend prolonged antibiotic use after urethral reconstruction.