2-[18F]-fluoro-2-desoxy-D-glucose positron emission tomography initial staging impacts on survival in Hodgkin lymphoma

• Published in: World journal of radiology Vol. 5; no. 12; pp. 484 - 490
• Main Authors: Cerci, Juliano J, Linardi, Camila C G, Pracchia, Luís F, Junior, José Soares, Trindade, Evelinda, Delbeke, Dominique, Cerci, Rodrigo J, Carr, Robert, Meneghetti, José C, Buccheri, Valeria
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Co., Limited 28-12-2013
• Subjects: 2-[18F]-fluoro-2-desoxy-D-glucose; Brief; disease; emission; Hodgkin; Neoplasm; positron; Positron-emission; Prognosis; staging; tomography; Positron-emission tomography; Hodgkin disease; 2-[18F]-fluoro-2-desoxy-D-glucose positron emission tomography; Prognosis; Neoplasm staging
• ISSN: 1949-8470; 1949-8470
• DOI: 10.4329/wjr.v5.i12.484

AIM:To assess the prognostic value and risk classification improvement of metabolic staging(MS)with Initial2-[18F]-fluoro-2-desoxy-D-glucose positron emission tomography(FDG-PET)in initial staging of Hodgkin’s Lymphoma(HL)patients to predict 5 years overall survival(5y-OS)and event free survival(EFS).METHODS:A total of 275 patients were included in this retrospective study,155 patients were staged with conventional anatomical staging(AS),and 120 also submitted to MS(FDG-PET).Prognostic analysis compared 5y-OS and 5y-EFS of patients staged with AS and MS.Risk-adjusted models incorporated clinical risk factors,computed tomography and FDG-PET staging.RESULTS:During the follow up of 267 evaluated patients,220(122 AS and 98 MS)achieved complete remission after first-line therapy(median follow-up:70±29 mo),treatment failure occurred in 79 patients and 34 died.The 5y-EFS for early vs advanced disease in AS patients was 79.3%and 66.7%,and 85.6%and53.6%in MS patients,respectively(P<0.01).The5y-OS for early and advanced disease with AS was91.3%and 81.5%,and 97.5%and 80.7%for patients staged with MS,respectively.Cox proportional hazards analysis demonstrated that FDG-PET added signifcant prognostic information and improved risk prediction(P=0.02).CONCLUSION:Initial staging FDG-PET could be used as an accurate and independent predictor of OS and EFS in HL,with impact in 5y-EFS and OS.