FAK and Pyk2 in disease

Focal adhesion kinase （FAK） and proline-rich tyrosine kinase 2 （Pyk2） are non-receptor protein tyrosine kinases that are involved in cell proliferation, migration and survival. Current research of FAK and Pyk2 is greatly focused in cancer biology and several small molecule inhibitors are being teste...

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Bibliographic Details
Published in:	Frontiers in biology Vol. 11; no. 1; pp. 1 - 9
Main Authors:	Murphy, James M., Park, Hyeonsoo, Lim, Ssang-Taek Steve
Format:	Journal Article
Language:	English
Published:	Beijing Higher Education Press 01-02-2016
Subjects:	Biochemistry Biomedical and Life Sciences Cell Biology Developmental Biology FAK Genetics and Population Dynamics Life Sciences Neurobiology Proteomics Pyk2 Review 心血管疾病慢性疾病神经系统疾病类风湿性关节炎粘着斑激酶蛋白酪氨酸激酶 FRNK FAK disease Pyk2
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Summary:	Focal adhesion kinase （FAK） and proline-rich tyrosine kinase 2 （Pyk2） are non-receptor protein tyrosine kinases that are involved in cell proliferation, migration and survival. Current research of FAK and Pyk2 is greatly focused in cancer biology and several small molecule inhibitors are being tested under clinical development. Like cancer, certain chronic diseases such as cardiovascular disease, bone disease, fibrosis, rheumatoid arthritis, and neurological disorders, share malignant characteristics of cancer. Accumulating evidence has demonstrated that FAK and Pyk2 contribute to other proliferative and degenerative diseases. Thus, the goal of this review is to briefly highlight studies that have implicated FAK and Pyk2 as players in disease progression.
Bibliography:	11-5892/Q Focal adhesion kinase （FAK） and proline-rich tyrosine kinase 2 （Pyk2） are non-receptor protein tyrosine kinases that are involved in cell proliferation, migration and survival. Current research of FAK and Pyk2 is greatly focused in cancer biology and several small molecule inhibitors are being tested under clinical development. Like cancer, certain chronic diseases such as cardiovascular disease, bone disease, fibrosis, rheumatoid arthritis, and neurological disorders, share malignant characteristics of cancer. Accumulating evidence has demonstrated that FAK and Pyk2 contribute to other proliferative and degenerative diseases. Thus, the goal of this review is to briefly highlight studies that have implicated FAK and Pyk2 as players in disease progression. FAK, Pyk2, FRNK, disease ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1674-7984 1674-7992
DOI:	10.1007/s11515-016-1384-4