Recovery of sit-to-stand function in patients with intensive-care-unit-acquired muscle weakness: Results from the General Weakness Syndrome Therapy cohort study

• Published in: Journal of rehabilitation medicine Vol. 48; no. 9; pp. 793 - 798
• Main Authors: Thomas, Simone, Burridge, Jane H, Pohl, Marcus, Oehmichen, Frank, Mehrholz, Jan
• Format: Journal Article
• Language: English
• Published: Sweden 12-10-2016
• Subjects: Cohort Studies; Female; Humans; Intensive Care Units; Length of Stay; Male; Middle Aged; Muscle Weakness - rehabilitation; Muscular Diseases - rehabilitation; Prospective Studies; Time Factors
• ISSN: 1650-1977; 1651-2081
• DOI: 10.2340/16501977-2135

To describe the time course of recovery of sit-to-stand function in patients with intensive-care-unit-acquired muscle weakness and the impact of recovery.
A cohort study in post-acute intensive care unit and rehabilitation units. Patients with chronic critical illness and intensive-care-unit-acquired muscle weakness were included. Sit-to-stand function was measured daily, using a standardized chair height, defined as 120% of the individual's knee height.
A total of 150 patients were recruited according to the selection criteria. The primary outcome of independent sit-to-stand function was achieved by a median of 56 days (interquartile range Q1-Q3 = 32-90 days) after rehabilitation onset and a median of 113 days (Q1-Q3=70-148 days) after onset of illness. The final multivariate model for recovery of sit-to-stand function included 3 variables: age (adjusted hazard ratio (HR) = 0.96 (95% CI 0.94-0.99), duration of ventilation (HR=0.99 (95% CI 0.98-1.00) and Functional Status Score for the Intensive Care Unit (FSS-ICU) (adjusted HR=1.12 (95% CI 1.08-1.16)).
Rapid recovery of sit-to-stand function for most patients with intensive-care-unit-acquired muscle weakness were seen. The variables older age and longer duration of ventilation decreased, and higher FSS-ICU increased the chance of regaining independent sit-to-stand function.