Chronical cervical infections and dysplasia (CIN I, CIN II): Vaginal vitamin D (high dose) treatment A new effective method?

• Published in: Dermato-endocrinology Vol. 6; no. 1; p. e27791
• Main Authors: Schulte-Uebbing, C, Schlett, S, Craiut, ID, Antal, L, Olah, H
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 2014; Landes Bioscience
• Subjects: cervicitis; cervix cancer; cervix dysplasia; cholecalciferol; CIN 1; CIN 2; colpitis; conization; PAP III D; vaginal vitamin D treatment; vitamin D; vitamin D3; vaginal vitamin D treatment; vitamin D; vitamin D3; CIN 2; cervicitis; cervix cancer; cholecalciferol; colpitis; CIN 1; cervix dysplasia; conization; PAP III D
• ISSN: 1938-1972; 1938-1980; 1938-1980
• DOI: 10.4161/derm.27791

In a small praxis/ambulance study we evaluated data of 200 women with chronical recurrent cervical infections and with a cervix dysplasia (CIN 1, CIN 2) who got after the primary therapy a treatment with vitamin D vaginal suppositories (12500 IU, 3 nights a week, for 6 weeks). We found that-when compared with the lactobacillus vaginal suppositories-the high dose vitamin D vaginal treatment might be more effective. Vitamin D showed very good anti-inflammatory effects. In the survey after six weeks therapy, 79% of the women had "less vaginal problems," "less discharge," and "less problems with the sexual intercourse." Objectively, after six weeks therapy, only 7% of the patients still had bacterial and/or fungal vaginal infections that required a treatment. We found that vitamin D is reabsorbed by the vaginal mucosa, but the reabsorption may be individually very different. In the CIN 1 group we found six weeks after treatment good antidysplastic effects, in the CIN 2 group we often found no or only temporary antidysplastic effects. So this vaginal vitamin D treatment method might be an option for the therapy and prevention of chronical cervical infections and maybe of a cervic dysplasia CIN 1 (good anti-inflammatory effects, antidysplastic effects). This small study is not representative. We need much bigger studies with much more dates and with a longer follow up. Caution: At the moment, we do not know if the vaginal vitamin D treatment with 12500 IE is possible in pregnancy. We have no experience. Therefore we recommend an effective contraception during the application.