Brief Report: Prolonged Viral Suppression Over a 12-Year Follow-up of HIV-Infected Patients: The Persistent Impact of Adherence at 4 Months After Initiation of Combined Antiretroviral Therapy in the ANRS CO8 APROCO-COPILOTE Cohort

• Published in: Journal of acquired immune deficiency syndromes (1999) Vol. 74; no. 3; pp. 293 - 297
• Main Authors: Protopopescu, Camelia, Carrieri, Maria P, Raffi, François, Picard, Odile, Hardel, Lucile, Piroth, Lionel, Jadand, Corinne, Pierret, Janine, Spire, Bruno, Leport, Catherine
• Format: Journal Article
• Language: English
• Published: United States Copyright Wolters Kluwer Health, Inc. All rights reserved 01-03-2017; Lippincott Williams & Wilkins Ovid Technologies
• Subjects: Adult; AIDS/HIV; Anthracenes; Anti-Retroviral Agents - administration & dosage; Antiretroviral drugs; Antiretroviral Therapy, Highly Active - methods; Correlation analysis; Female; Follow-Up Studies; HIV; HIV Infections - drug therapy; HIV Infections - psychology; HIV Infections - virology; Human immunodeficiency virus; Humans; Lentivirus; Male; Medication Adherence; Prospective Studies; Retroviridae; Sustained Virologic Response; Time Factors
• ISSN: 1525-4135; 1944-7884
• DOI: 10.1097/QAI.0000000000001249

The effect of early adherence on long-term viral suppression was assessed among 1281 patients with HIV starting a protease inhibitor-containing regimen in 1997–1999, followed up to 12 years. Association between 4-month adherence (3-level score) and prolonged viral suppression was evaluated using a multivariate mixed logistic model in 891 eligible patients. High 4-months adherence [odds ratio (95% confidence interval)3.72 (1.98 to 6.98)] was associated with long-term prolonged viral suppression, irrespective of maintenance adherence. This unexpected long-term virological impact of early adherence reinforces the message that, when starting antiretrovirals, all means should be mobilized to ensure optimum early adherence to achieve prolonged antiretroviral success.