Dynamic analysis of delayed vaccination process along with impact of retrial queues

• Published in: Computational and Mathematical Biophysics Vol. 11; no. 1; pp. 840 - 851
• Main Authors: Chauhan, Sudipa, Upadhyaya, Shweta, Rana, Payal, Malik, Geetika
• Format: Journal Article
• Language: English
• Published: De Gruyter 22-05-2023
• Subjects: 35A01; 65L10; 65L12; 65L20; 65L70; delay; dynamic analysis; retrial queues; RK method of fourth order; vaccination process
• ISSN: 2544-7297; 2544-7297
• DOI: 10.1515/cmb-2022-0147

An unprecedented and precise time-scheduled rollout for the vaccine is needed for an effective vaccination process. This study is based on the development of a novel mathematical model considering a delay in vaccination due to the inability to book a slot in one go for a system. Two models are proposed which involve a delay differential equation mathematical model whose dynamical analysis is done to show how the delay in vaccination can destabilize the system. Further, this delay led to the formulation of a queuing model that accounts for the need to retry for the vaccination at a certain rate as delay in vaccination can have negative repercussions. The transition rates from one stage to another follow an exponential distribution. The transient state probabilities of the model are acquired by applying the Runge-Kutta method and hence performance indices are also obtained. These performance measures include the expected number of people in various states. Finally, numerical analysis is also provided to validate both models. Our results would specifically focus on what happens if the delay time increases or if the retrial rate increases (delay time decreases). The results reveal that a delay in being vaccinated by the first dose (i.e., 80 days) leads to an unstable system whereas there exists a delay simultaneously in getting vaccinated by both doses that destabilize the system early (i.e., 80 and 120 days for dose one and two, respectively). The system destabilizes faster in the presence of a delay for slot booking for both doses as compared to one dose delay. Further, the numerical results of queuing models show that if the retrial rate increases in this delay time to book the slots, it not only increases in the vaccinated class but also increases the recovered population.