Structural and Functional Magnetic Resonance Imaging of Dementia With Lewy Bodies

Dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia after Alzheimer's disease (AD). Although diagnosis may be challenging, there is increasing evidence that the use of biomarkers according to 2017 revised criteria for diagnosis and management of dementi...

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Bibliographic Details
Published in:	International review of neurobiology Vol. 144; p. 95
Main Authors:	Balážová, Zuzana, Nováková, Marie, Minsterová, Alžběta, Rektorová, Irena
Format:	Journal Article
Language:	English
Published:	United States 2019
Subjects:	Humans Lewy Body Disease - diagnostic imaging Lewy Body Disease - physiopathology Magnetic Resonance Imaging - methods Functional White matter hyperintensities MRI Structural Resting state fMRI Quantitative susceptibility mapping Neuromelanin Nigrosome-1 Diffusion tensor imaging
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Summary:	Dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia after Alzheimer's disease (AD). Although diagnosis may be challenging, there is increasing evidence that the use of biomarkers according to 2017 revised criteria for diagnosis and management of dementia with Lewy bodies can increase diagnostic accuracy. Apart from nuclear medicine techniques, various magnetic resonance imaging (MRI) techniques have been utilized in attempt to enhance diagnostic accuracy. This chapter reviews structural, functional and diffusion MRI studies in DLB cohorts being compared to healthy controls, AD or dementia in Parkinson's disease (PDD). We also included relatively new MRI methods that may have potential to identify early DLB subjects and aim at examining brain iron and neuromelanin.
ISSN:	2162-5514
DOI:	10.1016/bs.irn.2018.10.005