Liquid Biopsy: From Basic Research to Clinical Practice

Liquid Biopsy: From Basic Research to Clinical Practice

Liquid biopsy refers to the molecular analysis in biological fluids of nucleic acids, subcellular structures, especially exosomes, and, in the context of cancer, circulating tumor cells. In the last 10 years, there has been an intensive research in liquid biopsy to achieve a less invasive and more p...

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Bibliographic Details
Published in:Advances in clinical chemistry Vol. 83; pp. 73 - 119
Main Authors: Macías, Mónica, Alegre, Estibaliz, Díaz-Lagares, Angel, Patiño, Ana, Pérez-Gracia, Jose L, Sanmamed, Miguel, López-López, Rafael, Varo, Nerea, González, Alvaro
Format: Journal Article
Language:English
Published: United States 2018
Subjects:
Pregnancy
Cell-free DNA
Liquid biopsy
microRNA
Transplantation
Circulating tumor cells
Exosomes
Cancer
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Summary:Liquid biopsy refers to the molecular analysis in biological fluids of nucleic acids, subcellular structures, especially exosomes, and, in the context of cancer, circulating tumor cells. In the last 10 years, there has been an intensive research in liquid biopsy to achieve a less invasive and more precise personalized medicine. Molecular assessment of these circulating biomarkers can complement or even surrogate tissue biopsy. Because of this research, liquid biopsy has been introduced in clinical practice, especially in oncology, prenatal screening, and transplantation. Here we review the biology, methodological approaches, and clinical applications of the main biomarkers involved in liquid biopsy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0065-2423
DOI:10.1016/bs.acc.2017.10.003