Facile 18F labeling of non-activated arenes via a spirocyclic iodonium(III) ylide method and its application in the synthesis of the mGluR5 PET radiopharmaceutical [18F]FPEB

Non-activated (electron-rich and/or sterically hindered) arenes are prevalent chemical scaffolds in pharmaceuticals and positron emission tomography (PET) diagnostics. Despite substantial efforts to develop a general method to introduce 18 F into these moieties for molecular imaging by PET, there is...

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Bibliographic Details
Published in:	Nature protocols Vol. 14; no. 5; pp. 1530 - 1545
Main Authors:	Liang, Steven H., Wang, Lu, Stephenson, Nickeisha A., Rotstein, Benjamin H., Vasdev, Neil
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-05-2019 Nature Publishing Group
Subjects:	631/1647/1888 631/1647/245/2092 639/638/403/933 639/638/903 Analytical Chemistry Aromatic compounds Benzonitrile Biological Techniques Biomedical and Life Sciences Computational Biology/Bioinformatics Fluorine isotopes Glutamic acid receptors (metabotropic) Injection Labeling Life Sciences Medical imaging Microarrays Organic Chemistry Pharmaceuticals Positron emission Positron emission tomography Precursors Protocol Purification Radiochemistry Radioisotopes Synthesis Tomography Tracers
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