Molecular and biochemical pharmacology of the histamine H 4 receptor

Molecular and biochemical pharmacology of the histamine H 4 receptor

The elucidation of the human genome has had a major impact on histamine receptor research. The identification of the human H 4 receptor by several groups has been instrumental for a new appreciation of the role of histamine in the modulation of immune function. In this review, we summarize the histo...

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Bibliographic Details
Published in:British journal of pharmacology Vol. 157; no. 1; pp. 14 - 23
Main Authors: Leurs, Rob, Chazot, Paul L, Shenton, Fiona C, Lim, Herman D, De Esch, Iwan JP
Format: Journal Article
Language:English
Published: 01-05-2009
Online Access:Get full text
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Summary:The elucidation of the human genome has had a major impact on histamine receptor research. The identification of the human H 4 receptor by several groups has been instrumental for a new appreciation of the role of histamine in the modulation of immune function. In this review, we summarize the historical developments and the molecular and biochemical pharmacology of the H 4 receptor.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.2009.00250.x