Unveiling the relationship between gut microbiota and heart failure: Recent understandings and insights

• Published in: Current problems in cardiology Vol. 49; no. 1 Pt C; p. 102179
• Main Authors: Jain, Hritvik, Marsool, Mohammed Dheyaa Marsool, Goyal, Aman, Sulaiman, Samia Aziz, Fatima, Laveeza, Idrees, Muhammad, Sharma, Bhavya, Borra, Vamsikalyan, Gupta, Prakash, Nadeem, Abdullah, Jain, Jyoti, Ali, Hassam, Sohail, Amir H
• Format: Journal Article
• Language: English
• Published: Netherlands 01-01-2024
• Subjects: Gut microbiota; Heart failure; Cardiovascular disease; Dysbiosis
• ISSN: 0146-2806; 1535-6280
• DOI: 10.1016/j.cpcardiol.2023.102179

Gut microbiota, which comprises a broad range of bacteria inhabiting the human intestines, plays a crucial role in establishing a mutually beneficial relationship with the host body. Dysbiosis refers to the perturbations in the composition or functioning of the microbial community, which can result in a shift from a balanced microbiota to an impaired state. This alteration has the potential to contribute to the development of chronic systemic inflammation. Heart failure (HF) is a largely prevalent clinical condition that has been demonstrated to have variations in the gut microbiome, indicating a potential active involvement in the pathogenesis and advancement of the disease. The exploration of the complex interplay between the gut microbiome and HF presents a potential avenue for the discovery of innovative biomarkers, preventive measures, and therapeutic targets. This review aims to investigate the impact of gut bacteria on HF.