Stenotrophomonas maltophilia bacteremia in children - A 10-year analysis

• Published in: Archivos argentinos de pediatría Vol. 118; no. 3; p. e317
• Main Authors: Büyükcam, Ayşe, Bıçakcıgil, Asiye, Cengiz, Ali B, Sancak, Banu, Ceyhan, Mehmet, Kara, Ateş
• Format: Journal Article
• Language: English
• Published: Argentina 01-06-2020
• Subjects: Adolescent; Anti-Bacterial Agents - adverse effects; Bacteremia - diagnosis; Bacteremia - etiology; Bacteremia - microbiology; Bacteremia - mortality; Catheter-Related Infections - diagnosis; Catheter-Related Infections - etiology; Catheter-Related Infections - microbiology; Catheter-Related Infections - mortality; Child; Child, Preschool; Cross Infection - diagnosis; Cross Infection - etiology; Cross Infection - microbiology; Cross Infection - mortality; Female; Gram-Negative Bacterial Infections - diagnosis; Gram-Negative Bacterial Infections - etiology; Gram-Negative Bacterial Infections - microbiology; Gram-Negative Bacterial Infections - mortality; Hospitalization; Humans; Infant; Infant, Newborn; Male; Retrospective Studies; Risk Factors; Stenotrophomonas maltophilia - immunology; Stenotrophomonas maltophilia; pneumonia; catheter related infection; bacteremia; child
• ISSN: 0325-0075; 1668-3501
• DOI: 10.5546/aap.2020.eng.e317

Stenotrophomonas maltophilia is a multidrug-resistant, Gramnegative, and biofilm-forming pathogen. Information is limited concerning S. maltophilia bacteremia in children. Clinical data and microbiological test results collected in a tertiary children's hospital over a ten-year period were reviewed. Children 0-18 years old who had positive clinical specimen, blood and/or catheter cultures were included. We identified 20 S. maltophilia isolates from 12 pediatric patients with confirmed infections. The median age was 28 months (range: 3.1-187.3). The rate of previous use of antimicrobial therapy was 83 %. The median antibiotic number was 3 (range: 0-7) within 30 days prior to onset of S. maltophilia bacteremia. Catheter related infection was the main infectious source (66.6 %). The mortality rate was 33.3 %. The death of two non-survivors was associated with pneumonia. S. maltophilia should be considered a breakthrough agent for bacteremia in children with underlying disease exposed to broad-spectrum antibiotics during long-term hospitalization.