The Importance of Ubiquitin E3 Ligases, SCF and APC/C, in Human Cancers

• Published in: Clujul medical Vol. 88; no. 1; pp. 9 - 14
• Main Authors: BOCHIS, OVIDIU VASILE, FETICA, BOGDAN, VLAD, CATALIN, ACHIMAS-CADARIU, PATRICIU, IRIMIE, ALEXANDRU
• Format: Journal Article
• Language: English
• Published: Iuliu Hatieganu University of Medicine and Pharmacy 2015
• Subjects: Review
• ISSN: 1222-2119; 2066-8872
• DOI: 10.15386/cjmed-377

A normal evolution of the cell-cycle phases consists of multiple consecutive events, which makes it a highly complex process. Its preservation is regulated by Cyclin-Cdks (cyclin-dependent kinases) interactions and protein degradation, which is often controlled by the ubiquitin-mediated proteolysis.
The goal of this review is to emphasize the most important features of the regulation of the cell-cycle involved in cancerogenesis, by presenting the involvement of E3 ubiquitin ligases SCF (Skp1-Cul1-F-box protein) and APC/C (Anaphase-promoting complex/cyclosome) in human malignancies. Also, we discuss the importance of the ubiquitin proteasome pathway blockade in cancer treatment. We know that a better understanding of the regulatory biology of the cell cycle can lead to the development of new target therapies for cancer.