Hyperestrogenemia resulting from a granulosa cell tumor and causing pulmonary thromboembolism: a case report

• Published in: Gynecological endocrinology Vol. 38; no. 6; pp. 531 - 533
• Main Authors: Ribeiro Dias-Junior, Altamiro, Vieira da Motta, Eduardo, Ferreira-Filho, Edson Santos, Evangelista Oliveira-Junior, Manoel Edinilson, Soares-Junior, José Maria, Baracat, Edmund Chada
• Format: Journal Article
• Language: English
• Published: England 01-06-2022
• Subjects: Estradiol; Female; Granulosa Cell Tumor - complications; Granulosa Cell Tumor - surgery; Humans; Inhibins; Middle Aged; Ovarian Neoplasms - pathology; Pulmonary Embolism - etiology; estrogen; hemostasis; Ovarian tumor
• ISSN: 0951-3590; 1473-0766
• DOI: 10.1080/09513590.2022.2047921

Estrogen modulates platelet activation and aggregation, and it increases the levels of the von Willebrand factor, factors II, VII, VIII, and X, and of fibrinogen, all of which increase the risk for thromboembolism. We report the case of a 59-year-old woman, postmenopausal for 4 years, not using hormone replacement therapy, who was admitted into the emergency room with shortness of breath and increased abdominal volume. After physical examination and imaging and biochemical tests, she was diagnosed with pulmonary thromboembolism and a large left adnexal tumor. The patient was promptly received full anticoagulation therapy for the pulmonary thromboembolism. High levels of estradiol (810.4 pg/mL), anti-Mullerian hormone (16.39 ng/mL), inhibin (11250 pg/mL), and suppressed FSH (<0.16 IU/L) led to a suspicion of granulosa-cell tumor. After clinical stabilization, she underwent to an exploratory laparotomy with total hysterectomy and bilateral adnexectomy to treat the pelvic tumor. Pathologic report confirmed a granulosa-cell tumor.