Use of Greater Wax Moth Larvae (Galleria mellonella) as an Alternative Animal Infection Model for Analysis of Bacterial Pathogenesis

Alternative infection models of bacterial pathogenesis are useful because they reproduce some of the disease characteristics observed in higher animals. Insect models are especially useful for modeling bacterial infections, as they are inexpensive, generally less labor-intensive, and more ethically...

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Bibliographic Details
Published in:	Methods in molecular biology (Clifton, N.J.) Vol. 1898; p. 163
Main Authors:	Kamal, Fatima, Peters, Danielle L, McCutcheon, Jaclyn G, Dunphy, Gary B, Dennis, Jonathan J
Format:	Journal Article
Language:	English
Published:	United States 2019
Subjects:	Animal Testing Alternatives - methods Animals Bacteria - genetics Bacteria - pathogenicity Bacterial Infections - genetics Bacterial Infections - microbiology Disease Models, Animal Humans Larva - genetics Larva - microbiology Moths - genetics Moths - microbiology Virulence - genetics Larvae Galleria mellonella Insects Pathogenesis Infection model Wax worm
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Summary:	Alternative infection models of bacterial pathogenesis are useful because they reproduce some of the disease characteristics observed in higher animals. Insect models are especially useful for modeling bacterial infections, as they are inexpensive, generally less labor-intensive, and more ethically acceptable than experimentation on higher organisms. Similar to animals, insects have been shown to possess innate immune systems that respond to pathogenic bacteria.
ISSN:	1940-6029
DOI:	10.1007/978-1-4939-8940-9_13