Prasugrel and Acquired Thrombotic Thrombocytopenic Purpura Associated with ADAMTS13 Activity Deficiency

We report a case of a 64-year-old man who, 44 days after starting treatment with prasugrel, presented with severe thrombocytopenia, anaemia, renal failure, and severe ADAMTS13 activity deficiency, along with a high titer of autoantibodies to this protease. Drug-induced TTP is a rare condition and di...

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Bibliographic Details
Published in:	European journal of case reports in internal medicine Vol. 3; no. 5; p. 000446
Main Authors:	Lopez, Yanet Parodis, Gonzalez, Nery Sablon, Villalba, Noel Lorenzo, Galvan, Rafael Camacho, Perez, Jose Carlos Rodriguez
Format:	Journal Article
Language:	English
Published:	Italy SMC Media Srl 2016 SMC MEDIA SRL
Subjects:	prasugrel Thrombotic microangiopathy thrombotic thrombocytopenic purpura Thrombotic microangiopathy prasugrel thrombotic thrombocytopenic purpura
Online Access:	Get full text
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Summary:	We report a case of a 64-year-old man who, 44 days after starting treatment with prasugrel, presented with severe thrombocytopenia, anaemia, renal failure, and severe ADAMTS13 activity deficiency, along with a high titer of autoantibodies to this protease. Drug-induced TTP is a rare condition and difficult to diagnose.Decreased activity of ADAMTS13, unusual in drug-induced TTP, was present in this case.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2284-2594 2284-2594
DOI:	10.12890/2016_000446