Unveiling the Mechanism of Protective Effects of Tanshinone as a New Fighter Against Cardiovascular Diseases: A Systematic Review

• Published in: Cardiovascular toxicology Vol. 24; no. 12; pp. 1467 - 1509
• Main Authors: Dabbaghi, Mohammad Mahdi, Soleimani Roudi, Hesan, Safaei, Rozhan, Baradaran Rahimi, Vafa, Fadaei, Mohammad Reza, Askari, Vahid Reza
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-12-2024; Springer Nature B.V
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Animal models; Biomedical and Life Sciences; Biomedicine; Blood pressure; Cardiology; Cardiovascular disease; Cardiovascular diseases; Cholesterol; Coronary artery disease; Coronary vessels; Cytokines; Diabetes; Endoplasmic reticulum; Growth factors; Heart attacks; Heart diseases; Hypertension; Ischemia; Kinases; Lipoproteins; MAP kinase; NF-κB protein; Nitric oxide; Oxidative stress; Peptides; Pharmacology/Toxicology; Proteins; Pulmonary arteries; Review; Smooth muscle; Systematic review; Tanshinones; Toxicology; Tumor necrosis factor-TNF; Vein & artery diseases; Cardiovascular disease; Myocardial fibrosis; Inflammation; Tanshinone; Cardiotoxicity; Salvia miltiorrhiza
• ISSN: 1530-7905; 1559-0259; 1559-0259
• DOI: 10.1007/s12012-024-09921-x

Tanshinone, a natural compound found in the roots of
Salvia miltiorrhiza
, has been shown to possess various pharmacological properties, including anti-inflammatory, antioxidant, and cardiovascular protective effects. This article aims to review the literature on the cardiovascular protective effects of tanshinone and its underlying mechanisms. Tanshinone has been demonstrated to improve cardiac function, reduce oxidative stress, and inhibit inflammation in various animal models of cardiovascular diseases. Additionally, it has been shown to regulate multiple signaling pathways involved in the pathogenesis of cardiovascular diseases, such as the PI
3
K/AKT, MAPK, and NF-κB pathways. Clinical studies have also suggested that tanshinone may have therapeutic potential for treating cardiovascular diseases. In conclusion, tanshinone has emerged as a promising natural compound with significant cardiovascular protective effects, and further research is warranted to explore its potential clinical applications.
Graphical Abstract