The association of cardiovascular disease risk with coronary artery calcification and thoracic aortic dilation: a study in idiopathic inflammatory myopathies and systemic lupus erythematosus

• Published in: Clinical rheumatology Vol. 43; no. 10; pp. 3117 - 3125
• Main Authors: Yang, Tianshu, Qiu, Yage, Zhang, Yiming, Hu, Wentao, Li, Muzi, Dai, Yongming, Zhou, Yan, Yin, Yan
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01-10-2024; Springer Nature B.V
• Subjects: Age; Aorta; Arteriosclerosis; Atherosclerosis; Biomarkers; Calcification; Calcification (ectopic); Cardiovascular disease; Cardiovascular diseases; Coronary artery; Coronary vessels; Correlation analysis; Interleukin 6; Lupus; Medicine; Medicine & Public Health; Original Article; Rheumatology; Risk factors; Systemic lupus erythematosus; Thorax; Idiopathic inflammatory myopathies; Coronary artery calcification; Thoracic aortic dilation; Systemic lupus erythematosus; Non-gated chest CT
• ISSN: 0770-3198; 1434-9949; 1434-9949
• DOI: 10.1007/s10067-024-07115-y

Objectives
We aim to explore the prevalence of coronary artery calcification (CAC) and ascending/descending thoracic aorta (AA/DA) dilation in idiopathic inflammatory myopathies (IIM) and systemic lupus erythematosus (SLE) patients, and to assess associations between cardiovascular disease (CVD) risk factors and these imaging signatures.
Methods
This study recruited 151 IIM patients, 140 SLE patients, and 195 controls. The CAC and AA/DA diameters were quantified using non-gated chest CT images. The independent samples
t
-test or Mann–Whitney test was chosen for comparisons of continuous variables between patients and healthy controls. For categorical data, comparisons were made using the chi-square test or Fisher’s exact test. Multivariate regression or Spearman’s correlation analysis was employed to probe the associations between CVD risk factors and Framingham risk score (FRS) with imaging signatures.
Results
The IIM and SLE patients showed significantly higher prevalence of CAC and AA/DA dilatation (
P
 < 0.01). Age was a risk factor for both CAC and AA/DA dilatation in all cohorts (
P
 < 0.01). In IIM patients, the AA/DA dilatation was associated with BMI (
P
 = 0.05). In SLE patients, CAC was associated with the elevated CRP level (
P
 = 0.05). Without CAC, both IIM and SLE patients showed significant correlations between AA/DA diameters and FRS (
P
 < 0.01,
P
 < 0.01). Only in SLE patients, the interleukin-6 (IL-6) level correlated with AA/DA diameters.
Conclusion
The IIM and SLE patients more commonly exhibit CAC and AA/DA dilation. These subclinical atherosclerosis signs are associated with traditional CVD risk factors. For AID patients without CAC, AA/DA diameters could serve as a potential biomarker for early CVD risk.
Key Points
•
The study characterized the manifestation of subclinical atherosclerosis imaging biomarkers (CAC, AA/DA dilation) in IIM and SLE patients.
•
AA/DA diameters could serve as an early imaging biomarker in clinical management for IIM and SLE patients with early-onset and no CAC present.