Eosinophilic esophagitis as paraneoplastic syndrome in a patient with ganglioneuroblastoma

• Published in: Klinische Padiatrie Vol. 227; no. 3; p. 173
• Main Authors: Prader, S, Spalinger, J, Caduff, J, Hürlimann, S, Rischewski, J
• Format: Journal Article
• Language: English
• Published: Germany 01-05-2015
• Subjects: Diagnosis, Differential; Eosinophilic Esophagitis - diagnosis; Eosinophilic Esophagitis - surgery; Ganglioneuroblastoma - diagnosis; Ganglioneuroblastoma - surgery; Humans; Infant; Male; Paraneoplastic Syndromes - diagnosis; Paraneoplastic Syndromes - surgery; Spinal Neoplasms - diagnosis; Spinal Neoplasms - surgery; Thoracic Vertebrae; Tomography, X-Ray Computed
• ISSN: 1439-3824
• DOI: 10.1055/s-0035-1547307

A 16-month-old boy presented with failure to thrive despite sufficient caloric intake, hypersalivation, abdominal pain, chronic diarrhea and blepharitis. An eosinophilic esophagitis (EoE) was diagnosed by esophageal biopsy. Dietary restrictions and topical steroid treatment lead to no improvement. Further diagnostic work-up revealed an intrathoracal, paraspinal ganglioneuroblastoma. After operative extirpation of the tumour, all initial symptoms resolved. An esophageal control biopsy 4 weeks after tumour resection was normal. This is the first report of eosinophilic esophagitis as part of a paraneoplastic syndrome in a patient with a malignant disease other than a carcinoma.