B cells instruct their own fate through IL-12

Extrafollicular and germinal center reactions are considered to represent sequential phases of a primary B cell response. A study now demonstrates the ability of autocrine IL-12 to promote extrafollicular differentiation into plasmablasts, while inhibiting germinal center responses.

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Bibliographic Details
Published in:	Nature immunology Vol. 25; no. 8; pp. 1310 - 1312
Main Author:	Sanz, Iñaki
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01-08-2024 Nature Publishing Group
Subjects:	631/250/127/1212 631/250/1619/40 631/250/1619/40/1742 631/250/2152/2153 Animals Autocrine signalling Autoimmune diseases B-Lymphocytes - immunology Biomedical and Life Sciences Biomedicine Cell culture Cell differentiation Cell Differentiation - immunology COVID-19 Disease Germinal centers Humans Immunology Infections Infectious Diseases Interleukin 12 Interleukin-12 - immunology Interleukin-12 - metabolism Lymphocytes Lymphocytes B Mice News & Views news-and-views Transcription factors
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Description
Summary:	Extrafollicular and germinal center reactions are considered to represent sequential phases of a primary B cell response. A study now demonstrates the ability of autocrine IL-12 to promote extrafollicular differentiation into plasmablasts, while inhibiting germinal center responses.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1529-2908 1529-2916 1529-2916
DOI:	10.1038/s41590-024-01887-w