ATR takes a crack at the nuclear envelope

ATR takes a crack at the nuclear envelope

In this issue, Joo et al. and Kovacs et al. report that the ATR kinase promotes nuclear envelope rupture through the phosphorylation of Lamin A/C, inducing processes such as cGAS-STING pathway activation, micronuclei clearance, and potentially cell death.

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Bibliographic Details
Published in:Molecular cell Vol. 83; no. 20; pp. 3588 - 3590
Main Authors: Smolka, Marcus B, Lammerding, Jan
Format: Journal Article
Language:English
Published: United States 19-10-2023
Subjects:
Ataxia Telangiectasia Mutated Proteins - genetics
Ataxia Telangiectasia Mutated Proteins - metabolism
Nuclear Envelope - metabolism
Nucleotidyltransferases - metabolism
Phosphorylation
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Description
Summary:In this issue, Joo et al. and Kovacs et al. report that the ATR kinase promotes nuclear envelope rupture through the phosphorylation of Lamin A/C, inducing processes such as cGAS-STING pathway activation, micronuclei clearance, and potentially cell death.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Commentary-3
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ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2023.09.031