Therapeutic Effects of Bacteroides fragilis Vesicles in a Model of Chemically Induced Colitis in Rats

• Published in: Bulletin of experimental biology and medicine Vol. 177; no. 5; pp. 626 - 629
• Main Authors: Shagaleeva, O. Yu, Kashatnikova, D. A., Vorobyeva, E. A., Kardonsky, D. A., Silantiev, A. S., Efimov, B. A., Ivanov, V. A., Bespyatikh, Yu. A., Zakharzhevskaya, N. B.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-09-2024; Springer Nature B.V
• Subjects: Abscesses; Animals; Anti-inflammatory agents; Bacteroides fragilis; Biomedical and Life Sciences; Biomedicine; Body weight; Cell Biology; Colitis; Colitis - chemically induced; Colitis - drug therapy; Colitis - microbiology; Colitis - pathology; Colon; Colon - drug effects; Colon - microbiology; Colon - pathology; Dextran; Dextran Sulfate - toxicity; Disease; Disease Models, Animal; Drinking water; Histology; Inflammatory bowel disease; Internal Medicine; Laboratory animals; Laboratory Medicine; Male; Medical research; Microscopy; Pathology; Pharmacology and Toxicology; Rats; Rats, Wistar; Sodium sulfate; Toxicology; Vesicles; rats; inflammatory bowel diseases; Bacteroides fragilis; dextran sulfate sodium; vesicles
• ISSN: 0007-4888; 1573-8221; 1573-8221
• DOI: 10.1007/s10517-024-06237-2

The anti-inflammatory properties of
Bacteroides fragilis
vesicles were studied in a rat model of dextran sodium sulfate-induced colitis. According to the histology results, addition of
B. fragilis
vesicles to the therapy promoted colon repair. Evaluation of the disease activity index confirms the high rate of colon recovery: against the background of vesicle administration, the absence of blood in stool, normal stool consistency, and body weight normalization were observed.