Genetic and biochemical mechanisms of involvement of antioxidant defense enzymes in the development of bronchial asthma

• Published in: Biomeditsinskaia khimiia Vol. 61; no. 4; p. 427
• Main Authors: Polonikov, A V, Ivanov, V P, Bogomazov, A D, Solodilova, M A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-07-2015
• Subjects: Asthma - enzymology; Asthma - genetics; Asthma - pathology; Bronchi - enzymology; Bronchi - pathology; Catalase - genetics; Catalase - metabolism; Gene Expression; Genetic Predisposition to Disease; Glutamate-Cysteine Ligase - genetics; Glutamate-Cysteine Ligase - metabolism; Glutathione Peroxidase - genetics; Glutathione Peroxidase - metabolism; Glutathione Peroxidase GPX1; Glutathione Transferase - genetics; Glutathione Transferase - metabolism; Humans; NAD(P)H Dehydrogenase (Quinone); NADPH Oxidases - genetics; NADPH Oxidases - metabolism; Oxidative Stress; Peroxidase - genetics; Peroxidase - metabolism; Polymorphism, Genetic; biochemical abnormalities; bronchial asthma; etiology and pathogenesis; free radical processes; genetic polymorphism; antioxidant defense enzymes; oxidative stress
• ISSN: 2310-6972
• DOI: 10.18097/PBMC20156104427

In the present review we have analyzed and summarized recent literature data on genetic and biochemical mechanisms responsible for involvement of antioxidant defense enzymes in the etiology and pathogenesis of bronchial asthma. It has been shown that the mechanisms of asthma development are linked with genetically determined abnormalities in the functioning of antioxidant defense enzymes. These alterations are accompanied by a systemic imbalance between oxidative and anti-oxidative reactions with the shift of the redox state toward increased free radical production and oxidative stress, a key element in the pathogenesis of bronchial asthma.