The effect of multiple sclerosis therapy on gut microbiota dysbiosis: a longitudinal prospective study

• Published in: Microbial cell Vol. 11; pp. 106 - 115
• Main Authors: Paraschiv, Andreea-Cristina, Vacaras, Vitalie, Nistor, Cristina, Vacaras, Cristiana, Strilciuc, Stefan, Muresanu, Dafin F
• Format: Journal Article
• Language: English
• Published: Austria Shared Science Publishers OG 06-04-2024
• Subjects: brain gut axis; demyelinating autoimmune disorders; gut microbiota; immunoglobulin y; immunomodulation; microbiome; multiple sclerosis; immunoglobulin Y; immunomodulation; demyelinating autoimmune disorders; multiple sclerosis; brain gut axis; microbiome; gut microbiota
• ISSN: 2311-2638; 2311-2638
• DOI: 10.15698/mic2024.04.819

Gut microbiota has complex immune functions, related to different pathologies, including multiple sclerosis (MS).This study evaluated the influence of treatments on gut microbiota in people with MS (PwMS). The research comprised 60 participants, including 39 PwMS and 21 healthy controls (HC). Among the PwMS, 20 were prescribed a disease-modifying therapy (DMT), either interferon beta1a or teriflunomide, while 19 received a combination of classical DMT and an immunoglobulin Y (IgY) supplement. For each participant, two sets of gut samples were collected: one at the study's outset and another after two months. Alpha and beta diversity analyses revealed no significant differences between groups. In comparison to the HC, the MS group exhibited an increase in
and a decrease in
. Following treatment, individuals with MS showed enrichment in
and
. The second sample, compared to the first one, demonstrated an increase in
and a decrease in
for individuals with MS. Gut microbiota diversity in PwMS is not significantly different to HC.However, specific taxonomic changes indicate the presence of a dysbiosis state. The use of DMTs and immunoglobulin Y supplements may contribute to alterations in microbial composition, potentially leading to the restoration of a healthier microbiome.