Phenotype of human T helper and suppressor cells in an in vitro specific antibody response

Monoclonal anti-human T cell antibodies have been used to identify cells which provide help for an in vitro specific antibody response to influenza virus and also those which suppress the response of allogeneic peripheral blood mononuclear cells. The helper cells carry antigens defined by the Leu 3a...

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Bibliographic Details
Published in:	European journal of immunology Vol. 12; no. 3; p. 232
Main Authors:	Callard, R E, Smith, C M, Beverley, P C
Format:	Journal Article
Language:	English
Published:	Germany 1982
Subjects:	Antibodies, Monoclonal - immunology Antibody Formation Antigens, Surface - genetics Cell Separation - methods Fluorescent Antibody Technique Humans In Vitro Techniques Influenza A virus - immunology Lymphocyte Cooperation Phenotype Serology T-Lymphocytes - immunology T-Lymphocytes, Regulatory - immunology
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Summary:	Monoclonal anti-human T cell antibodies have been used to identify cells which provide help for an in vitro specific antibody response to influenza virus and also those which suppress the response of allogeneic peripheral blood mononuclear cells. The helper cells carry antigens defined by the Leu 3a and OKT4-antisera, whereas the suppressor cells are predominantly Leu 2a- and OKT8-positive. Help and suppression in this secondary in vitro antibody response are therefore provided by antigenically distinct T cell subsets.
ISSN:	0014-2980
DOI:	10.1002/eji.1830120312