A Copper Complex of a Thiosemicarbazone-Pyridylhydrazone Ligand Containing a Vinylpyridine Functional Group as a Potential Imaging Agent for Amyloid-β Plaques

• Published in: Critical studies in media communication Vol. 72; no. 10; p. 827
• Main Authors: McInnes, Lachlan E, Noor, Asif, Roselt, Peter D, McLean, Catriona A, White, Jonathan M, Donnelly, Paul S
• Format: Journal Article
• Language: English
• Published: Collingwood CSIRO 01-01-2019
• Subjects: Brain; Coordination compounds; Copper; Copper compounds; Crystallography; Diagnostic systems; Disease; Electrochemical analysis; Functional groups; Hydrazones; Ligands; Medical imaging; Positron emission; Radiochemistry; Radioisotopes; Room temperature; Sulfur; Voltammetry
• ISSN: 1529-5036
• DOI: 10.1071/CH19311

Complexes containing positron-emitting radionuclides of copper have the potential to be of use for diagnostic imaging with positron emission tomography. Alzheimer’s disease is characterised by the presence of amyloid-? plaques in the brain. A new thiosemicarbazone-pyridyl hydrazone tetradentate ligand with a pyridyl-4-vinylpyridine functional group was prepared with the aim of making a copper complex that binds to amyloid-? plaques to assist in the diagnosis of Alzheimer’s disease. The ligand forms a charge neutral complex with copper(ii) that was characterised by X-ray crystallography and the electrochemical behaviour of the complex was investigated by cyclic voltammetry. The new ligand can be radiolabelled with positron-emitting copper-64 at room temperature in excellent radiochemical yields. The new complex interacts with synthetic amyloid-? fibrils and binds amyloid-? plaques present in post-mortem Alzheimer’s disease brain tissue.