Long-term survival after R0 resection of thymoma

• Published in: Asian cardiovascular & thoracic annals Vol. 26; no. 6; pp. 461 - 466
• Main Authors: Koçer, Bulent, Kaplan, Tevfik, Günal, Nesimi, Koçer, Bilge Gönenli, Akkaş, Yucel, Yazkan, Rasih, Dural, Koray, Kulaçoğlu, Sezer, Han, Serdar
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01-07-2018
• Subjects: Female; Follow-Up Studies; Forecasting; Humans; Male; Middle Aged; Neoplasm Staging; Retrospective Studies; Survival Rate - trends; Thoracic Surgery, Video-Assisted - methods; Thymectomy - methods; Thymoma - diagnosis; Thymoma - mortality; Thymoma - surgery; Thymus Neoplasms - diagnosis; Thymus Neoplasms - mortality; Thymus Neoplasms - surgery; Turkey - epidemiology; Thymectomy; Neoplasm staging; Thymoma; Neoplasm recurrence; Survival rate; local; Age groups
• ISSN: 0218-4923; 1816-5370
• DOI: 10.1177/0218492318778634

Background
The aim of this study was to evaluate the results of R0 resection of thymoma to identify prognostic factors for long-term outcomes.
Methods
Data of 62 patients (28 male, 34 female) with a mean age of 47.26 ± 14.42 years, who underwent R0 resection for thymoma and were followed-up between February 2004 and March 2016, were analyzed retrospectively.
Results
Eight patients had a video-assisted thoracoscopic thymectomy and 54 had a transsternal extended thymectomy. During a mean follow-up of 128.67 ± 7.95 months, regional recurrence of thymoma was observed in 9 (14.5%) patients. Overall 5- and 10-year survival rates were 85.36% and 78.20%, respectively. The 5- and 10-year survival rates in patients aged < 50 years were significantly better than in those aged ≥ 50 years (92% and 72% vs. 88% and 39%, p < 0.0001). The 10-year overall survival of patients in Masaoka stage I and II was better than those in stage III (88.9%, 78.4%, 69.8%, respectively, log-rank p < 0.001). The 10-year survival of patients with World Health Organization histological type A, AB, and B1 thymomas was better than those with type B2 and B3 (log-rank test p < 0.001). In multivariate analysis, age < 50 years (p = 0.001), Masaoka stage (p = 0.006), histological type (p = 0.001), and recurrence (p = 0.04) were independent prognostic factors for survival.
Conclusion
Our study indicates that age < 50 years, Masaoka stage, histological type, and recurrence are the determinants of survival in surgically resected cases of thymoma.