Genetic factors influencing HIV entry into target cells

Genetic factors influencing HIV entry into target cells

Succeptibility to HIV and the dynamics of HIV infection progression to AIDS are dependent on unique individual factors. Revealing genetic features of natural resistance to HIV infection is of great importance for the development of effective strategies for disease control. This review presents an an...

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Bibliographic Details
Published in:Bi͡u︡lletenʹ Sibirskoĭ medit͡s︡iny Vol. 18; no. 1; pp. 131 - 141
Main Authors: Khaitov, R. M., Alexeev, L. P., Kofiadi, I. A., Gudima, G. O.
Format: Journal Article
Language:English
Published: Siberian State Medical University (Tomsk) 16-05-2019
Subjects:
аллели
вич
гены
патогенез
рецепторы
устойчивость/чувствительность к вич-инфекции
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Summary:Succeptibility to HIV and the dynamics of HIV infection progression to AIDS are dependent on unique individual factors. Revealing genetic features of natural resistance to HIV infection is of great importance for the development of effective strategies for disease control. This review presents an analysis of host gene alleles coding receptors and their ligands participating in viral entrance to target cell. These allelic variants and their combinations can have a significant influence on the individual resistance/sensitivity to HIV infection and may be associated with the HIV infection progression to AIDS.
ISSN:1682-0363
1819-3684
DOI:10.20538/1682-0363-2019-1-131-141