Lactones 20 : Biohydroxylation of saturated bicyclic γ-lactones with the substituted cyclohexane system

Three bicyclic saturated γ-lactones with various numbers of methyl groups at the cyclohexane ring were transformed into the corresponding hydroxylactones. The most effective biohydroxylations were performed by means of cultures Fusarium culmorum and Absidia cylindrospora. Biotransformations of lacto...

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Bibliographic Details
Published in:	Journal of molecular catalysis. B, Enzymatic Vol. 29; no. 1-6; pp. 13 - 18
Main Authors:	Gładkowski, Witold, Grabarczyk, Małgorzata, Konopka, Monika, Wawrzeñczyk, Czesław
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Amsterdam Elsevier B.V 21-06-2004 Elsevier Science
Subjects:	Absidia cylindrospora Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Biotransformations Fundamental and applied biological sciences. Psychology Fusarium culmorum Hydroxylations Lactones Methods. Procedures. Technologies Fusarium culmorum Hydroxylations Absidia cylindrospora Biotransformations Lactones Hydroxylation Phycomycetes Lactone Fungi Absidia Biotransformation Cyclohexane Fungi Imperfecti Thallophyta
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Summary:	Three bicyclic saturated γ-lactones with various numbers of methyl groups at the cyclohexane ring were transformed into the corresponding hydroxylactones. The most effective biohydroxylations were performed by means of cultures Fusarium culmorum and Absidia cylindrospora. Biotransformations of lactones 4a and b afforded the hydroxylactones with the secondary hydroxy groups (5a and b), whereas the hydroxy group introduced into the lactone 4c turned out to be tertiary giving the product 5c.
ISSN:	1381-1177 1873-3158
DOI:	10.1016/j.molcatb.2003.10.012