The role of polymorphism of genes eotaxin (–384) and CCR3 (–51) in formation of blood eosinophilia under pulmonary tuberculosis

The role of polymorphism of genes eotaxin (–384) and CCR3 (–51) in formation of blood eosinophilia under pulmonary tuberculosis

With attracting contemporary molecular-genetic and immunological research methods, it has been established that blood eosinophilia under pulmonary tuberculosis is mediated by hypersecretion eotaxin. Susceptibility to the emergence of eosinophilic blood reaction under tubercular infection is associat...

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Bibliographic Details
Published in:Bi͡u︡lletenʹ Sibirskoĭ medit͡s︡iny Vol. 11; no. 6; pp. 213 - 215
Main Authors: K. O. Miheeva, Yu. V. Kolobovnikova, O. I. Urazova, V. V. Novitsky, O. V. Filinyuk, M. D. Goncharov, I. O. Naslednikova
Format: Journal Article
Language:English
Published: Siberian State Medical University (Tomsk) 28-12-2012
Subjects:
полиморфизм генов
рецепторы
цитокины
эозинофилия
эотаксин
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Summary:With attracting contemporary molecular-genetic and immunological research methods, it has been established that blood eosinophilia under pulmonary tuberculosis is mediated by hypersecretion eotaxin. Susceptibility to the emergence of eosinophilic blood reaction under tubercular infection is associated with the allele G and homozygous genotype GG of the polymorphic region A-384G of the gene eotaxin as well as with allele С and homozygous genotype СС polymorphism T-51C of the gene ССR3.
ISSN:1682-0363
1819-3684
DOI:10.20538/1682-0363-2012-6-213-215