Cardiac Amyloidosis Associated with Apolipoprotein A-IV Deposition Diagnosed by Mass Spectrometry-Based Proteomic Analysis

Amyloidosis is a group of disorders characterised by the accumulation of extracellular deposits of insoluble protein aggregates. Clinical management depends on the accurate identification of the amyloid precursor and underlying cause. We describe a rare case of apolipoprotein A-IV cardiac amyloidosi...

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Bibliographic Details
Published in:	European journal of case reports in internal medicine Vol. 6; no. 12; p. 001237
Main Authors:	Martins, Elisabete, Urbano, Joana, Leite, Sérgio, Pinto, Adriana, Garcia, Raquel, Bergantim, Rui, Rodrigues-Pereira, Pedro, Costa, Paulo Pinho, Osório, Hugo, Tavares, Isabel
Format:	Journal Article
Language:	English
Published:	Italy SMC Media Srl 27-11-2019 SMC MEDIA SRL
Subjects:	amyloidosis apolipoprotein cardiomyopathy heart failure imaging nuclear medicine heart failure apolipoprotein Amyloidosis cardiomyopathy nuclear medicine imaging
Online Access:	Get full text
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Summary:	Amyloidosis is a group of disorders characterised by the accumulation of extracellular deposits of insoluble protein aggregates. Clinical management depends on the accurate identification of the amyloid precursor and underlying cause. We describe a rare case of apolipoprotein A-IV cardiac amyloidosis, the diagnosis of which required mass spectrometry-based proteomic analysis. To be able to perform the differential diagnosis of cardiac amyloidosis subtypes using imaging methods, analytical results and tissue analysis.To recognise the added value of mass spectrometry (MS)-based proteomic analysis.
ISSN:	2284-2594 2284-2594
DOI:	10.12890/2019_001237