Understanding the effects of lysergic acid diethylamide and the importance of its prevention

• Published in: Health sciences review (Oxford, England) Vol. 8; p. 100107
• Main Authors: Okumuş, Burak, Metin, Ahmet, Kariper, İ. Afşin
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01-09-2023; Elsevier
• Subjects: Lysergic acid diethylamide; Pharmacokinetic effects; Physicochemical properties; Psychiatric effects; Receptor effect mechanism; Psychiatric effects; Pharmacokinetic effects; Receptor effect mechanism; Lysergic acid diethylamide; Physicochemical properties
• ISSN: 2772-6320; 2772-6320
• DOI: 10.1016/j.hsr.2023.100107

This review is on lysergic acid diethylamide (LSD), which has a halogenic effect and is addictive. Up to now, LSD has been used for pleasure-inducing or spiritual purposes. Since it is soluble in water, it can be administered in different forms. The final decision about whether it is addictive or not is undecided. The use of LSD is extensive and is also used for treating psychiatric disorders such as depression, post-traumatic stress disorder, and addiction. In this review, firstly, general information on LSD was explained. Then, its physicochemical properties (solubility, melting point, stability), pharmacokinetics, receptor interactions, mechanism of action, studies with healthy subjects (subjective effects, autonomic and endocrine effects, psychiatric effects), and preventive studies against addiction effects were discussed. Finally, there are recommendations for the use of LSD.