Leveraging spray drying technique for advancing biologic product development–A mini review

Over the last 15 years, spray drying (SD), as an alternative to lyophilization, to manufacture and increase the stability of biologics has demonstrated promising outcomes. Pharmaceutical companies, on the other hand, have yet to expand technology for the production of aseptic spray-dried biologics....

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Bibliographic Details
Published in:	Health sciences review (Oxford, England) Vol. 10; p. 100142
Main Authors:	Donthi, Mahipal Reddy, Butreddy, Arun, Saha, Ranendra Narayan, Kesharwani, Prashant, Dubey, Sunil Kumar
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01-03-2024 Elsevier
Subjects:	Biologics Instability Powder dosage form Protein formulation Spray drying Stabilization Spray drying Instability Protein formulation Stabilization Powder dosage form Biologics
Online Access:	Get full text
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Summary:	Over the last 15 years, spray drying (SD), as an alternative to lyophilization, to manufacture and increase the stability of biologics has demonstrated promising outcomes. Pharmaceutical companies, on the other hand, have yet to expand technology for the production of aseptic spray-dried biologics. In this mini-review, we have discussed the limitations and potential of SD in biologics production.
ISSN:	2772-6320 2772-6320
DOI:	10.1016/j.hsr.2023.100142