New Antimicrobial Polymeric Microspheres Containing Azomethine

• Published in: Journal of inorganic and organometallic polymers and materials Vol. 32; no. 10; pp. 3971 - 3982
• Main Authors: Ülke, Eyüp, Hasanoğlu Özkan, Elvan, Nartop, Dilek, Öğütcü, Hatice
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-10-2022; Springer Nature B.V
• Subjects: Bacteria; Biomedical materials; Chemical analysis; Chemistry; Chemistry and Materials Science; Copper; Differential thermal analysis; E coli; Fungicides; Inorganic Chemistry; Klebsiella; Magnetic permeability; Manganese; Microspheres; Organic Chemistry; Polymer Sciences; Polymeric microspheres; Tris(2-aminoethyl)amine polymer-bound; Antimicrobial activity
• ISSN: 1574-1443; 1574-1451
• DOI: 10.1007/s10904-022-02411-z

Herein, new polymeric microspheres containing azomethine (PS–OPA, PS–OPA–Pt, PS–OPA–Ni, PS–OPA–Mn and PS–OPA–Cu) were synthesized and investigated by elemental analysis, FT-IR, SEM–EDX, TGA–DTA, UV–Vis, GPC and magnetic susceptibility. Antibacterial and antifungal activities of the synthesized polymeric microspheres were evaluated against pathogenic bacteria (
Staphylococcus epidermidis
ATCC12228
, Bacillus cereus
RSKK863
, Staphylococcus aureus
ATCC25923
, Enterobacter aerogenes, Pseudomonas aeroginosa
sp.
, Klebsiella pneumonia
ATCC27853
, Salmonella type
H NCTC9018394
, Proteus vulgaris
RSKK96026
, Escherichia coli
ATCC1280) and yeast (
Candida albicans
Y-1200-NIH) by the well-diffusion method for potential biomedical applications. It was determined that polymeric microspheres exhibited higher inhibition effect against
B. cereus
,
E. aerogenes
,
P. aeruginosa
,
P. vulgaris
and showed higher antifungal activity than standard nystatin.
Graphical Abstract