Frontispiece: An Aromatic Hydroxyamide Attenuates Multiresistant Staphylococcus aureus Toxin Expression

• Published in: Chemistry : a European journal Vol. 22; no. 5; pp. np - n/a
• Main Authors: Vomacka, Jan, Korotkov, Vadim S., Bauer, Bianca, Weinandy, Franziska, Kunzmann, Martin H., Krysiak, Joanna, Baron, Oliver, Böttcher, Thomas, Lorenz-Baath, Katrin, Sieber, Stephan A.
• Format: Journal Article
• Language: English
• Published: Weinheim Blackwell Publishing Ltd 26-01-2016; Wiley Subscription Services, Inc
• Subjects: Attenuation; Bacteria; Biochemistry; Biocompatibility; Biomedical materials; Chemistry; click chemistry; Contracts; Derivatives; drug discovery; Human; medicinal chemistry; proteomics; Reinforcement; Staphylococcus aureus; Strategy; Surgical implants; toxicology; Virulence; Virulence factors
• ISSN: 0947-6539; 1521-3765
• DOI: 10.1002/chem.201680562

Anti‐Virulence Strategy The agreement depicted in the figure is between humans, who, instead of killing bacterial cells, just reduce their arsenal of virulence factors, and Staphylococcus aureus which, as a reward, do not respond with resistance development. In their Full Paper on page 1622 ff., S. A. Sieber et al. report that the molecule represented in the middle and on the contract is one of the most powerful among a set of hydroxyamide derivatives to exhibit this remarkable bioactivity.