Photodynamic therapy mediated by a red LED and methylene blue inactivates resistant Leishmania amazonensis

Cutaneous leishmaniasis is a neglected parasitic disease that leads to destructive lesions. The emergence of drug resistance has been a global concern over the past years. Photodynamic therapy (PDT) mediated by a red LED and methylene blue (MB) involves the overproduction of oxidative stress, which...

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Bibliographic Details
Published in:	Journal of the Optical Society of America. A, Optics, image science, and vision Vol. 40; no. 5; p. 996
Main Authors:	Cabral, Fernanda V, Yoshimura, Tania M, Teixeira da Silva, Daniela de Fátima, Cortez, Mauro, Ribeiro, Martha S
Format:	Journal Article
Language:	English
Published:	United States 01-05-2023
Subjects:	Humans Leishmania Leishmaniasis, Cutaneous - drug therapy Leishmaniasis, Cutaneous - parasitology Leishmaniasis, Cutaneous - pathology Methylene Blue - pharmacology Methylene Blue - therapeutic use Photochemotherapy
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Summary:	Cutaneous leishmaniasis is a neglected parasitic disease that leads to destructive lesions. The emergence of drug resistance has been a global concern over the past years. Photodynamic therapy (PDT) mediated by a red LED and methylene blue (MB) involves the overproduction of oxidative stress, which oxidizes several cellular biomolecules and prevents the selection of resistant strains. Herein, we investigated the potential of PDT mediated by MB against wild-type and miltefosine-resistant strains of Leishmania amazonensis. As a result, both strains were susceptible to PDT, thus encouraging us to seek the best conditions to overcome the drug resistance problem in cutaneous leishmaniasis.
ISSN:	1520-8532
DOI:	10.1364/JOSAA.482314