Influence of infection at the time of root filling on the outcome of endodontic treatment of teeth with apical periodontitis

• Published in: International endodontic journal Vol. 30; no. 5; pp. 297 - 306
• Main Authors: SJÖGREN, U., FIGDOR, D., PERSSON, S., SUNDQVIST, G.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-09-1997
• Subjects: bacteria; Bacteria - isolation & purification; Bacterial Infections - microbiology; Bacterial Infections - pathology; Bacterial Infections - therapy; Biopsy; Dental Disinfectants - therapeutic use; Dental Pulp Cavity - microbiology; Dentistry; Follow-Up Studies; Humans; Immunohistochemistry; one visit treatment; Periapical Periodontitis - microbiology; Periapical Periodontitis - pathology; Periapical Periodontitis - therapy; Periapical Tissue - metabolism; Periapical Tissue - microbiology; Periapical Tissue - pathology; prognosis; Root Canal Obturation - instrumentation; Root Canal Obturation - methods; root filling; Sodium Hypochlorite - therapeutic use; success rate; Time Factors; Treatment Outcome
• ISSN: 0143-2885; 1365-2591
• DOI: 10.1046/j.1365-2591.1997.00092.x

Summary
This study investigated the role of infection on the prognosis of endodontic therapy by following‐up teeth that had had their canals cleaned and obturated during a single appointment. The root canals of 55 single‐rooted teeth with apical periodontitis were thoroughly instrumented and irrigated with sodium hypochlorite solution. Using advanced anaerobic bacteriological techniques, post–instrumentation samples were taken and the teeth were then root‐filled during the same appointment. All teeth were initially infected; after instrumentation low numbers of bacteria were detected in 22 of 55 root canals. Periapical healing was followed up for 5 years. Complete periapical healing occurred in 94% of cases that yielded a negative culture. Where the samples were positive prior to root filling, the success rate of treatment was just 68%– a statistically significant difference. Further investigation of three failures revealed the presence of Actinomyces species in each case; no other specific bacteria were implicated in failure cases. These findings emphasize the importance of completely eliminating bacteria from the root canal system before obturation. This objective cannot be reliably achieved in a one‐visit treatment because it is not possible to eradicate all infection from the root canal without the support of an inter–appointment antimicrobial dressing.