A Front-End CMOS Interface Circuit with High Voltage Charge Pump and Oscillator for Capacitive Micromachined Ultrasonic Transducers

• Published in: IEEE transactions on circuits and systems. II, Express briefs Vol. 70; no. 5; p. 1
• Main Authors: Zhao, Yihe, Barbruni, Gian Luca, Li, Zhikang, Zhao, Libo, Wang, Xiaozhang, Wang, Kaifei, Jiang, Zhuangde, Carrara, Sandro
• Format: Journal Article
• Language: English
• Published: New York IEEE 01-05-2023; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Antibodies; application-specific integrated circuit (ASIC); Biomolecules; Biosensors; Capacitive micromachined ultrasonic transducers (CMUTs); Charge pumps; Circuits; CMOS; Energy dissipation; Feedback; feedback oscillator; high voltage charge pump; High voltages; High-voltage techniques; Low temperature; Micromachining; Monitoring; Nucleic acids; Oscillators; Resonant frequencies; Resonant frequency; Resonators; Sensitivity; Transducers; Ultrasonic transducers
• ISSN: 1549-7747; 1558-3791
• DOI: 10.1109/TCSII.2023.3261061

Label-free biosensors, combined with miniaturized micro-electromechanical sensory platforms, offer an attractive solution for real-time and facile monitoring of biomolecules due to their high sensitivity and selectivity without the need for specifically labeling. Resonators have been acknowledged as an efficient technology for measuring biomolecular binding events including those involving nucleic acid and antibody. Among these, capacitive micromachined ultrasonic transducers (CMUTs) have emerged as a promising candidate for biosensing. However, their usage is often limited by the requirement for high voltage supply and continuous frequency tracking, which can result in significant parasitic effects and measurement errors. In this paper, we present a novel front-end interface circuit for a CMUTs-based biosensor. The circuit, fabricated using TSMC 0.18-μX;Jm Bipolar-CMOS-DMOS (BCD) technology, incorporates an on-chip high voltage charge pump and feedback frequency monitoring. The CMUTs array features 20×20 circular cells, fabricated using a low-temperature direct bonding technology, with an experimental parallel-resonant frequency of 1.724 MHz and a high quality factor of up to 40.9. To fit the measured electrical characteristics, a five-element equivalent lumped element model is proposed. The high voltage charge pump provides an output voltage of 20 V, while the feedback oscillator has a ms-level start-up time and a total power dissipation of 3.8 mW. The proposed front-end interface is designed to function as a stand-alone chip for CMUTs-based resonant biodetection.