Effects of Antiepileptic Drugs on Bone Density and Metabolism

Many studies have demonstrated that both classic (e.g., phenobarbital, carbamazepine, valproate) and new antiepileptic drugs (e.g., oxcarbazepine, gabapentin) decrease bone metabolism. Abnormalities in calcium metabolism often occur on inducing the cytochrome P450 enzyme system, thus decreasing vita...

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Bibliographic Details
Published in:	Archives of Epilepsy Vol. 23; no. 1; pp. 1 - 6
Main Authors:	Zeynep AYDIN ÖZEMİR, Ayşe Destina YALÇIN
Format:	Journal Article
Language:	English
Published:	Galenos Yayinevi 01-04-2017
Subjects:	antiepileptic drugs calcium metabolism decrease in bone mineral density
Online Access:	Get full text
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Summary:	Many studies have demonstrated that both classic (e.g., phenobarbital, carbamazepine, valproate) and new antiepileptic drugs (e.g., oxcarbazepine, gabapentin) decrease bone metabolism. Abnormalities in calcium metabolism often occur on inducing the cytochrome P450 enzyme system, thus decreasing vitamin D levels. However, the reason some antiepileptic drugs that suppress (e.g., valproate) or have no effect on this system also affect vitamin D metabolism is not known. This study explored the effect of classic and new antiepileptic drugs on bone health and calcium metabolism.
ISSN:	2792-0550
DOI:	10.14744/epilepsi.2016.93723