Absence of history of oral cleft in first-degree relatives of patients with prostate cancer

• Published in: Dentistry 3000 Vol. 7; no. 1; pp. 37 - 42
• Main Authors: De Alvarenga Diniz Fonseca, Cláudia, Reis Barbosa Martelli, Daniella, Freitas Almeida, Ianná Luana, Hassen Sales, Galeno, Soares de Andrade, Rodrigo, Oliveira Dias, Verônica, Monteiro de Barros, Letízia, Martelli Júnior, Hercílio
• Format: Journal Article
• Language: English
• Published: Pittsburgh University Library System, University of Pittsburgh 25-07-2019
• Subjects: Birth defects; cancer; Family medical history; Heredity; Mouth; Oral clefts; prostate; Prostate cancer
• ISSN: 2167-8677; 2167-8677
• DOI: 10.5195/d3000.2019.88

Objective: To evaluate the occurrence of nonsyndromic cleft lip and/or palate (NSCL/P) in families of patients with prostate cancer (PC).Study design: We conducted a case-control study involving a total of 748 individuals, 280 of which had PC, and 468 were free-cancer healthy individuals. The patients answered a questionnaire with basic demographic information and family history of NSCL/P in first-degree relatives. The information collected was stored in a database and analyzed by using the statistical program SPSS® 24.0 for Windows (Chicago, IL, USA). In order to determine the association with NSCL/P, chi-square and Fisher’s exact test and odds ratio (OR) with its 95% confidence interval (95% CI) for risk magnitude assessment. Values with p<0.05 were considered statistically significant.Results: Of total patients with PC, 2 had a positive history of NSCL/P. In the control group, 7 patients reported family history of NSCL/P (1df chi-square, p=0.34; Fisher´s exact test, p=0.49). The average age of the cases diagnosed with PC was 71.35±7.70 years, and control group was 64.42±9.67 years.Conclusion: Despite the limited population, the frequency of NSCL/P was not significantly increased in the first-degree relatives of patients with PC. Studies with larger samples and molecular analyses are needed to better understand the possible relationships in the etiology of cancer and NSCL/P.