Hydrophilic sulfur-containing antioxidant sodium 3-(3-tert-butyl-4-hydroxyphenyl)propylthiosulfate as a modulator of the activity of antitumor cytostatics and their combinations with a NO donor

• Published in: Russian chemical bulletin Vol. 71; no. 3; pp. 517 - 523
• Main Authors: Bogatyrenko, T. N., Kandalintseva, N. V., Sashenkova, T. E., Allayarova, U. Yu, Mishchenko, D. V.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-03-2022; Springer Nature B.V
• Subjects: Anticancer properties; Antioxidants; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Doxorubicin; Full Articles; Inorganic Chemistry; Leukemia; Nitric oxide; Organic Chemistry; Sodium nitrite; Sulfur; Survival; nitric oxide; doxorubicin; cisplatin; sulfur-containing phenolic antioxidant; metronomic therapy
• ISSN: 1066-5285; 1573-9171
• DOI: 10.1007/s11172-022-3442-1

The interaction of a combination of a sulfur-containing phenolic antioxidant sodium 3-(3-
tert
-butyl-4-hydroxyphenyl)propylthiosulfate (TS-13) with a nitric oxide donor (NaNO
2
) and two antitumor cytostatics, cisplatin and doxorubicin, was studied
in vivo
using a model of P-388 murine leukemia of BDF
1
mice. It has been shown that the type of cytostatics used determines the efficiency of chemotherapy. Depending on this, the antioxidant TS-13 can both enhance and reduce the antitumor effect. The use of TS-13 and a nitric oxide donor with different cytostatics and different modes of drug administration modulates their activity in different ways, namely, from increasing survival to inhibition of survival.