Iron overload and iron chelation therapy in thalassaemia and sickle cell haemoglobinopathies

This paper reviews the factors governing the rate of iron loading and iron toxicity in the thalassaemia syndromes and sickle cell disease. It outlines the main determinants of iron mobilization by the iron-chelating drug, desferrioxamine, together with the effects of this drug in clinical practice.

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Bibliographic Details
Published in:	Acta haematologica Vol. 78; no. 2-3; p. 206
Main Author:	Pippard, M J
Format:	Journal Article
Language:	English
Published:	Switzerland 1987
Subjects:	Anemia, Sickle Cell - drug therapy Ascorbic Acid - therapeutic use Deferoxamine - therapeutic use Drug Administration Schedule Forecasting Humans Iron - blood Iron Chelating Agents - therapeutic use Sickle Cell Trait - drug therapy Thalassemia - drug therapy
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Description
Summary:	This paper reviews the factors governing the rate of iron loading and iron toxicity in the thalassaemia syndromes and sickle cell disease. It outlines the main determinants of iron mobilization by the iron-chelating drug, desferrioxamine, together with the effects of this drug in clinical practice.
ISSN:	0001-5792
DOI:	10.1159/000205876