Vitiligo is associated with a significant increase in HLA-A30, Cw6 and DQw3 and a decrease in C4AQ0 in northern Italian patients

HLA polymorphisms of class I (HLA-A, B, C) of class II (HLA-DR, DQ) and of class III (C4A, C4B, BF) were investigated in 93 Northern Italian patients affected with vitiligo and in 388 controls. Vitiligo patients had significant increases in HLA-A30 (corrected p, pc = 0.0144), Cw6 (pc = 0.0189), DQw3...

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Bibliographic Details
Published in:	Dermatology (Basel) Vol. 185; no. 2; p. 123
Main Authors:	Orecchia, G, Perfetti, L, Malagoli, P, Borghini, F, Kipervarg, Y
Format:	Journal Article
Language:	English
Published:	Switzerland 1992
Subjects:	Adolescent Adult Aged Child Electrophoresis Female HLA-A Antigens - blood HLA-C Antigens - blood HLA-DQ Antigens - blood Humans Italy Male Middle Aged Phenotype Polymorphism, Genetic - immunology Vitiligo - genetics Vitiligo - immunology Italy
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Summary:	HLA polymorphisms of class I (HLA-A, B, C) of class II (HLA-DR, DQ) and of class III (C4A, C4B, BF) were investigated in 93 Northern Italian patients affected with vitiligo and in 388 controls. Vitiligo patients had significant increases in HLA-A30 (corrected p, pc = 0.0144), Cw6 (pc = 0.0189), DQw3 (pc less than 0.0003) and a significant decrease in C4AQ0 (pc = 0.003). Nonfamilial vitiligo is marked by increases in HLA-A30 and DQw3. Extensive vitiligo is marked by increases in HLA-A30 and Cw6. These findings suggest that immunogenetic mechanisms may be responsible for vitiligo and that unique HLA phenotypes may influence the expression of vitiligo in this population.
ISSN:	1018-8665
DOI:	10.1159/000247426