Lysine‐Based Two‐Component Organogelator: Naproxen Carrier Soft Material

• Published in: ChemistrySelect (Weinheim) Vol. 8; no. 46
• Main Authors: Çolak, Mehmet, Kaya, Gülşen, Adnan Hayaloğlu, Ali, Demirel, Nadir, Hoşgören, Halil
• Format: Journal Article
• Language: English
• Published: 12-12-2023
• Subjects: Controlled drug release; low molecular weight organogelators (LMWOGs); Rheology; Small molecule gelling agent (SMGA); Supramolecular gels
• ISSN: 2365-6549; 2365-6549
• DOI: 10.1002/slct.202302968

We demonstrated that Nϵ ‐alkanoyl‐L‐lysine ethyl ester/N‐alkanoyl‐L‐phenylalaninate gelling agents were constructed as a two‐component gelling strategy and applied as drug carriers in friendly solvents commonly used. Our designs are expected to have an edge in contrast to the other lipid‐based systems due to cheap raw materials, reducing the required amount of carrier, low molecular weight, ease of loading, simple dose adjustability, skin spreadability, and improved drug retention times. It could be loaded with Naproxen (Npx) with a high loading efficiency (up to 100 % as a percentage of gelator) without gel disruption. A complementary in vitro drug release study under specific pH was conducted and performed at different drug and gelator concentrations. These results reveal that the release of Npx from the supramolecular organogels was significantly retarded with increasing organogelator engagement from 0.46 % to 0.92 %, the initial release rate considerably reduced, from 18.75 % to 7.21 %, respectively; that is release rate shows a 2.6‐fold decrease; this result showed that the gelator concentration could control drug release. whereas the increasing Npx concentration enhanced it. Altogether, this work produces valuable outcomes, which may be relevant to the pharmaceutical industry, suggesting that new platforms may deliver NSAID ( non‐steroidal anti‐inflammotory drug) molecules.
The study showed controlled release of naproxen was achieved with high loading efficiency (up to 100 % in percent gelator) with different drug and gelator concentrations without damaging the gel structure.