A study of the procoagulant properties of amniotic fluid and their correlation with the lecithin/sphingomyelin ratio

The procoagulant properties of amniotic fluid have been studied in samples taken throughout pregnancy and the results correlated with the lecithin/sphingomyelin ratio: acceleration effects on the prothrombin time. Russell's viper venom test, activated partial thromboplastin time and specific fa...

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Bibliographic Details
Published in:	British journal of obstetrics and gynaecology Vol. 88; no. 2; p. 133
Main Authors:	English, C J, Poller, L, Burslem, R W
Format:	Journal Article
Language:	English
Published:	England 01-02-1981
Subjects:	Amniotic Fluid - analysis Amniotic Fluid - physiology Blood Coagulation Factor VII - analysis Factor X - analysis Female Humans Lung - embryology Partial Thromboplastin Time Phosphatidylcholines - analysis Pregnancy Prothrombin Time Sphingomyelins - analysis
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Summary:	The procoagulant properties of amniotic fluid have been studied in samples taken throughout pregnancy and the results correlated with the lecithin/sphingomyelin ratio: acceleration effects on the prothrombin time. Russell's viper venom test, activated partial thromboplastin time and specific factor VII and X assays and contact acceleration. Although amniotic fluid is shown to function as a complete thromboplastin and to activate factor X directly, none of these tests of procoagulant activity of amniotic fluid is a reliable index of fetal lung maturity.
ISSN:	0306-5456
DOI:	10.1111/j.1471-0528.1981.tb00956.x