Pituitary Stalk Interruption Syndrome: A Case Report

• Published in: Curēus (Palo Alto, CA) Vol. 14; no. 10
• Main Authors: Ziad, Alishbah, Khan, Quratulain, Farooq, Hira, Rehman, Anis, Siddique, Kashif
• Format: Journal Article
• Language: English
• Published: Palo Alto Cureus Inc 12-10-2022; Cureus
• Subjects: Amenorrhea; Case reports; Endocrinology/Diabetes/Metabolism; Growth hormones; Hormone replacement therapy; Hypothalamus; Insulin-like growth factors; Magnetic resonance imaging; Mutation; Other; Pituitary gland; Radiology
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.30218

Pituitary stalk interruption syndrome is a congenital abnormality. The triad of this syndrome comprises a thin pituitary stalk, an ectopic posterior pituitary gland, and an absent or hypoplastic anterior pituitary gland. The patient typically presents with a spectrum of symptoms secondary to anterior pituitary hormonal deficiency. The etiology of this syndrome is not established but is likely due to a genetic mutation. The prognosis is good if the syndrome is diagnosed early and hormonal therapy is started promptly. Early diagnosis is crucial in preventing adverse effects on growth and development. The diagnosis of pituitary stalk interruption syndrome is based on magnetic resonance imaging (MRI) findings.This study presents the case of a young girl who presented with complaints of short stature and amenorrhea and was diagnosed with pituitary stalk interruption syndrome following an MRI.