Hijacking of the methylglyoxal detoxification pathway: a new tactic of Xoo pathogenesis in rice

• Published in: Physiologia plantarum Vol. 176; no. 4; pp. e14439 - n/a
• Main Authors: Kumar, Parvesh, Kumari, Poonam, Mehra, Rakesh, Singh, Bahaderjeet, Kumar, Rakesh
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-07-2024; Wiley Subscription Services, Inc
• Subjects: Adaptability; Bioaccumulation; Blight; Detoxification; Gene Expression Regulation, Plant; Host-Pathogen Interactions; Immune response; Inactivation, Metabolic; Oryza - metabolism; Oryza - microbiology; Pathogenesis; Pathogens; Plant cells; Plant Diseases - microbiology; Plant Proteins - genetics; Plant Proteins - metabolism; Pyruvaldehyde; Pyruvaldehyde - metabolism; Rice; Stresses; Virulence; Xanthomonas - pathogenicity; Xanthomonas - physiology
• ISSN: 0031-9317; 1399-3054; 1399-3054
• DOI: 10.1111/ppl.14439

Xanthomonas oryzae pv. oryzae (Xoo), the causative agent of bacterial blight (BB), has developed a unique strategy to infect rice by hijacking the host's methylglyoxal (MG) detoxification pathway. This results in an over‐accumulation of MG, which facilitates tissue colonization and evasion of host's immune responses. While MG role in abiotic stresses is well‐documented, its involvement in biotic stresses has not been extensively explored. Recently, Fu et al. (2024) provided the first evidence of MG role in promoting Xoo pathogenesis in rice. This new virulence strategy contributes to the pathogen's remarkable adaptability and survival. In this mechanism of hijacking of MG detoxification pathway, Xoo induces OsWRKY62.1 to inhibit OsGLY II expression, leading to MG overaccumulation in infected rice cells. This excess MG hinders plant cell organelle function, creating a favorable environment for Xoo by compromising the rice defense system. In this article, we have presented our perspectives on how the BB pathogen adapts its virulence mechanisms to infect and cause disease in rice.